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Validation of SERS NPs with explanted xenograft tumors: A) Representative spectra for A431 tumors labeled ex vivo with three different NP types: targeted (dots; via anti-EGFR affibody), targeted with competitive inhibition (solid), and untargeted (dashes; blank). Specific signals arise from the targeted NPs. B) Collections of spectra create Raman maps from whole tumors and signal quantitated in (C). Error bars represent the standard error and * indicates significance at p < 0.01.
