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A: Non-CpG methylation of mESCs, Dnmt KOs and differentiated cells. Non-CpG methylation can be found at Afp at 4 CpA positions (16, 23, 34, 45) and on one CpT position (54). Dnmt3a together with Dnmt3L are responsible for this methylation, Dnmt3bKO shows only slight effect. B: Correlation plot for cytosine methylation at Dnmt1KO ESCs at Afp. Methylated CpA positions mostly correlate to methylated neighboured CpG positions.
