Fig. 7.

Soluble TNF rescues the prostate regression phenotype of Tnf^−/− mice but is not sufficient to induce regression in the absence of castration. A, Representative MR image series of mice before castration (P) as well as 4 and 8 d after castration. MR images from two additional Tnf^−/− animals from the group analyzed in Fig. 2B are included for comparison. B, VP regression after castration in WT, Tnf^−/− and Tnf^−/− plus sTNF. WT and Tnf^−/− data (from Fig. 2) are included for comparison. C, Representative MR image series of mice before treatment (P) as well as 4 and 8 d after treatment as indicated. D, VP volume (percent of pretreatment volume) in WT noncastrated mice receiving either sTNF or PBS by injection. n = 4 for each set of animals. Bars, sem. *, P < 0.05 by ANOVA.