TABLE 10A.
Pharmacologic challenge in the MOUSE (oral peanut oil)
| Author | Test | Age and Route of Exposure | Age Testing | Sample Size Per Dose Level of Challenge Drug (Yes/No litter is unit) | Challenge Drug | Measure∗ | Effect of Challenge Drug on Controls | Effect of CPF on the Effect of Challenge Drug Magnitude of CPF Dose 6 mg/kg-day |
|---|---|---|---|---|---|---|---|---|
| Venerosi et al., 2010 | Forced Swimming Test Videotaped and blind Not balanced |
GD 15–18 Oral Peanut Oil |
adulthood | 12M+6F from unstated number of litters Litter included as factor in analysis |
Fluvoxamine (5 HT uptake inhibitor) 30 mg/kg i.p. |
Swimming frequency | M↑ F0 | M↓ (Attenuate) |
| Swimming duration | M↑ F↑ | M↓ F↓ (Attenuate) | ||||||
| Struggling frequency | M↑ F0 | M↓ (Attenuate) | ||||||
| Struggling duration | M↑ F0 | M↓ (Attenuate) | ||||||
| Floating duration | M↓ F(↓) p=0.07 | M and F Attenuate | ||||||
| Venerosi et al., 2010 | Maternal AggressionMale mouse placed in home cage with the dam and her empty nest Videotaped and blind frequency(f), duration (d), and latency (l) measured for each parameter |
GD 15–18 Oral Peanut Oil |
Females only, 8 days after delivery of pups | 5–7 F from unstated number of litters Litter included as factor in analysis |
Fluvoxamine (5HT uptake inhibitor) 30 mg/kg i.p. |
Fighting behavior – attack (3 different cage areas) f,d,l |
F↓ f and d for 2–3 cage areas | F attenuate duration of in-nest attack Note: CPF also ↓ baseline levels |
| Social behavior –social sniffing (3 subtypes) f,d,l |
F↑ duration inactivity in-nest | F attenuate duration inactivity in-nest | ||||||
| Non-social behavior(3 subtypes) f,d,l |
F0 | No effect of fluvoxamine, but CPF increased basal levels in 1 of 3 subtypes |