TABLE 11.

CPF effects on brain or RBC AChE inhibition in rats

	Selected Rat Brain or RBC AChE inhibitiona for developmental period of exposure
	GD 9–12 (dams exposed)	GD 17–20 (dams exposed)	PND 1–4 (pups exposed)	PND 10–16 or 11–14 (pups exposed)
CPF s.c. exposures (Brain AChE inhibition in rat offspring)	1 and 5 mg/kg: Not measured	1 mg/kg: 0 (24 hr)  2 mg/kg: 20% (24 hr) (Qiao et al., 2002)  5 mg/kg: 50% (24 hr) (Qiao et al., 2002)	1 mg/kg: 25% (24 hr) Song et al., 1997 1 mg/kg: 75% (2 hr after PND1 dose) Dam et al., 2000	PND 10–16 5 mg/kg 73% (4 hr)Carr and Nail, 2008 PND 11–14 5 mg/kg >65% (24 hr) Song et al., 1997
CPF oral exposures (Brain AChE inhibition in rat offspring)	GD 6–20 1 mg/kg: 0 (4 hr) 5 mg/kg: 60% (4 hr) (Mattsson et al., 2000)			PND 10–16 5 mg/kg >58% (4hr) Carr and Nail, 2008
CPF oral exposures (RBC AChE inhibition in dams)	GD 6–20 0.3 mg/kg: >25% dam RBC AChE Inhibition (4 hr) 1 mg/kg: >80% dam RBC AChE inhibition (4 hr) (Mattsson et al., 2000)

^aGreatest effect from selected publication was reported, with 0 indicating no effect