TABLE 6A.

Motor activity in the RAT (oral corn oil)

						Magnitude of Dose Tested, mg/kg-day
Author	Test	Age Exposure	Age Testing	Sample Size Per Dose Level (Yes/No litter is unit)	Measure*	0.3	1	3	5	3, 6a	3,6,12a
Maurissen et al., 2000	Home Cage Activity (1 hour)Automated Time of testing balanced across dose level and sex	GD6-PND10 Oral corn oil	PND 13	N = 20 litters; 1 pup/sex/litter Yes, litter is unit, Litter was a factor in the statistical analysis	Total Activity	0b	0		(↓)c
					Habituation	0	0		0
			PND 17		Total Activity	0	0		(↑)
					Habituation	0	0		0
			PND 21		Total Activity	0	0		(↑)
					Habituation	0	0		0
			PND 60		Total Activity	0	0		(↑)
					Habituation	0	0		0
Carr et al., 2001	Open Field (3 min for PND 10,12; 6 min for PND 14–20) Video camera, measures from 2 technicians averaged for each rat; blind and semi-balanced	PND 1–21 (pups dosed every other day) Oral corn oil	PND 10, 12, 14, 16, 18, 20	2 males and 2 females per litter from 5 litters Yes, litter is unit, Litter was a factor in the statistical analysis	Line crosses (front 2 paws)			M0 F0 for each of 6 ages		M0 F0 for each of 6 ages	M0 F0 for each of 6 ages
			PND 25			M0 F0		M↓ F↓	M↓ F↓
			PND 30			M0 F0		M↓ F↓	M↓ F↓

^aCarr 2001 dosed animals with incrementally higher doses as animals got older

^bAll entries without “M” and/or “F” indicates analyses is based on males and females combined.

^c() indicates changes reported by the authors were not statistically significant

^*If statistical analyses or measures were described in methods, then it was included and listed as “0” if not reported to be statistically significant