TABLE 7B.
Novelty/plus maze in the RAT (sc DMSO)
| Magnitude of Dose Tested, mg/kg-day | |||||||
|---|---|---|---|---|---|---|---|
| Author | Test | Age and route of Exposure | Age Testing | Sample Size per Dose Level (Yes/No Litter is Unit) | Measure* | 1 | 5 |
| Icenogle et al., 2004 | Elevated plus maze Not blind |
GD 9–12 sc DMSO |
Not stated | 10 M +10 F; 10 litters (1 rat /sex/reconstituted litter) Litter of origin is not unit due to randomization of pups to dams at birth. |
Time spent in open versus closed arm | 0 | 0 |
| Center crossing | 0 | ↑ | |||||
| Aldridge et al., 2005a | Elevated plus maze Not blind |
PND1–4 sc DMSO |
PND 52–53 (Wk 7) | 1 pup/sex/ litter; 9 litters Litter is not unit for initial pooled analysis combining M & F |
Open arm time | M↑ F0 (reduced “anxiety”) | |
| Center crossing | M↑ F0 | ||||||
*
If statistical analyses or measures were described in methods, it was included and listed as “0” if not reported to be statistically significant.