TABLE 9A.

Learning and memory (rat oral corn oil)

						Magnitude of Dose Tested mg/kg-day
Author	Test	Age and Route of Exposure	Age Testing	Sample Size per Dose Level (Yes/No litter is unit)	Measure∗	0.3	1	3	5
Maurissen et al., 2000	Spatial delayed alternation	GD 6-PND10	PND 22–24	N=16 litters; 1 male OR 1 female pup per litter from 16 litters	% correct	0b	0		0
			a85% free-feeding weight		acquisition	0	0		0
					retention	0	0		0
	Blind	Oral, corn oil	PND 61–90	Yes, litter is unit	% correct	0	0		0
	No feed restrction		a 85% free-feeding bodyweight		acquisition	0	0		0
					retention	0	0		0
Incremental dose regimen							1	1, 2 & 4c	1.5, 3 & 6d
Johnson et al., 2009	Radial arm maze	PND1–21	PND36–60	Within-litter design for methyl-parathion and chlorpyrifos doses	Working errors analyzed by week		M↑e F0	M↑e F0	M↑ F0
	Not Blind	Oral, corn oil	agradual 95–90—80% of feed	Yes, litter is unit	Working error overall		M0 F0	M0 F0	M↑ F0
				N=10–14 rats/sex/dose group	Reference errors analyzed by week		M0F0	M0 F↓	M↑ F↓
	Gradual feed reduction (95%–90% to 80% over 4 weeks				Reference errors cumulative		M0 F0	M0 F↓	M↑ F↓
					Response time (seconds per entry)		0	0	0

^aAnimals were feed restricted based on free-feeding weight or amount of feed

^bEntries without “M” and/or “F” indicate analyses was based on pooling data for males and females

^cIncremental dosing regimen from 1.0 (PND1–5) to 2.0 (PND6–13) to 4.0 (PND14–20) mg/kg-day

^dIncremental dosing regimen from 1.5 (PND1–5) to 3.0 (PND6–13) to 6.0 (PND14–20) mg/kg-day

^eIncrease errors (3.2 vs. 2.7 in controls approximated from graph) during 4th week but not first 3 weeks. No overall effect on total working errors at low and mid dose

^*If statistical analyses or measures were described in methods, it was included and listed as “0” if not reported to be statistically significant