TABLE 9C.

Learning and memory (mouse sc DMSO)

Author	Test	Age Exposure	Age Testing	Sample Size Per Dose Level Yes/No litter is unit)	Measure∗	1	3	5	10
Billauer-Haimovitch et al., 2009	Morris MazeVideo monitored, not blind	GD9–18 sc DMSO	PD 75	1 pup/sex/litter; 7–17 litters/group Litter is not unit. Half pups cross-fostered at birth; males and females from same litter pooled together; litter was not a factor in the analysis	Latency	↑a,b (deficit)	↑a (deficit)	0a	0a
Haviland et al., 2010	Radial Arm Maze	GD17–20	PD 60	8 litters/dose group	Working error	0		0
	Not blind	sc DMSO	Mice were fasted	Yes, litter is unit# pups / litter was not reported	Reference error	0		0
	Foraging Maze Not blind	GD17–20 sc DMSO	PD 60	8 litters/dose group Yes, litter is unit# pups / litter was not reported	Food recognition: Food pieces found per reward baited arm	M↑c F↓ (male improve, female deficit)		M0c F↓ (female deficit)
					Food Position: # correct looks left where bait is per total looks in baited arm	M0c F↓ (female deficit)		M0c F↓ (female deficit)
					Foraging activity	M0 F0		M0 F0
Ricceri et al., 2003	Passive Avoidance Not blind	PD 1–4 sc DMSO	PD 60	8 or 9 males with at least 1 male/litter; total 36 litters for 4 groups	Trials to criterion	M0	M0
					Latency to step through	M0	M0
				Pup and not litter was the unit	24 hr. retention	M0	M0
Ricceri et al., 2003	Passive Avoidance No blind	PD 11–14 sc DMSO	PD 60	7–10 males with at least 1 male/litter; total 36 litters for 4 groups	Trials to criterion	M0	M0
					Latency to step through	M0	M0
				Pup and not litter was the unit	24 hr. retention	M0	M0

^aEntries without “M” and/or “F” indicate analyses was based on males and females pooled together in a single analyses because there was no significant interaction between dose and sex.

^bInspection of data indicates significant overlap of learning curve with controls

^cIncrease (↑) means improvement in learning compared to controls. Decrease (↓) means deficit or delay in learning compared to controls

^*If statistical analyses or measures were described in methods, it was included and listed as “0” if not reported to be statistically significant