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A new branch of TLR3 signaling. The Src-dependent branch of TLR3 signaling pathway is distinct from the gene induction branch. DsRNA-stimulated dimerization of TLR3 leads to Src recruitment, its auto-phosphorylation leading to transient functional activation, followed by sequestration in the lipid rafts as an inactive pool, causing inhibition of cell migration, proliferation and adhesion.
