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. 2012 May 10;4(5):800–832. doi: 10.3390/v4050800

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Fusion machinery of herpesviruses. All herpesviruses utilize gB and gHgL for membrane fusion. Different herpesviruses have different accessory proteins involved in regulation of membrane fusion. gD is used by alpha herpes viruses (HSV), and porcine herpesvirus (PRV) uses gp50. Beta herpesviruses (HCMV) use UL128, UL130, and UL131. Gamma herpesviruses (EBV) use accessory protein gp42. The only structures that are currently known can be accessed from the PDB database: HSV-1 gB, 2GUM; HSV-2 gHgL, 3M1C; HSV-1 gD, 2C36; EBV gB, 3FVC; EBV gHgL, 3PHF; EBV gp42, 3FD4; PRV gH, 2XQY.