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Fusion machinery of HSV. The minimal set of proteins required for HSV membrane fusion is depicted to scale. gB is structurally conserved across all herpesviruses, while gH/gL is more variable. gD is the accessory fusion protein required for membrane fusion in HSV. gD determines cell tropism by binding cellular receptors HVEM or Nectin-1. All proteins are colored according to their structural regions, as defined previously for HSV gD, HSV gH/gL, HSV gB, HVEM and Nectin-1.
