Table 1.

CBZ metabolized with time as determined by HPLC-UV

	0 h	24 h	48 h	72 h	% Metabolized (0–72 h)
Media only Hepatocytes	45.42 ± 0.01	48.86 ± 0.55	49.95 ± 1.79	45.77 ± 0.46	0
Media only HBMEC	45.22 ± 0.20	46.91 ± 0.68	46.40 ± 1.19	44.43 ± 0.63	1.7
No-shear HBMEC	47.04 ± 0.02	39.36 ± 0.05	39.18 ± 0.09	37.56 ± 0.10	20.2
Shear HBMEC	44.85 ± 0.40	40.77 ± 0.41	35.80 ± 1.13	31.95 ± 1.33	28.7
Hepatocytes	43.25 ± 0.01	35.65 ± 0.54	29.77 ± 1.54	26.24 ± 1.09	39.3
EPI-EC	64.91 ± 0.35	56.27 ± 1.95	47.15 ± 1.07	37.92 ± 1.84	41.6

Data are expressed as mean values (μg/ml) ± SE (n = 4 experiments/condition). Data are relative to sampling performed at indicated time points.