Table 2.
Association of concentricity with decline in eGFRcr and eGFRcys among MESA participants with baseline eGFRcr ≥60 ml/min per 1.73 m2 by linear mixed models
| Predictors | n | Demographic Adjusted Change in eGFRa | Fully Adjusted Change in eGFRb |
|---|---|---|---|
| eGFRcr | |||
| concentricity | |||
| continuous (per SD=0.24) | 3866 | −0.18 (−0.24, −0.12) | −0.14 (−0.20, −0.08) |
| quartile (g/ml) | |||
| 1 (<0.95 for women, <1.06 for men) | 966 | Reference | Reference |
| 2 (0.95–1.06 for women, 1.06–1.17 for men) | 967 | −0.15 (−0.30, 0.01) | −0.11 (−0.26, 0.04) |
| 3 (1.07–1.20 for women, 1.18–1.35 for men) | 967 | −0.12 (−0.27, 0.03) | −0.08 (−0.23, 0.08) |
| 4 (≥1.20 for women, ≥1.35 for men) | 966 | −0.44 (−0.60, −0.28) | −0.32 (−0.49, −0.15) |
| eGFRcys | |||
| concentricity | |||
| continuous (per SD=0.24) | 3866 | −0.13 (−0.21, −0.05) | −0.09 (−0.18, −0.003) |
| quartile (g/ml) | |||
| 1 (<0.95 for women, <1.06 for men) | 966 | Reference | Reference |
| 2 (0.95–1.06 for women, 1.06–1.17 for men) | 967 | −0.14 (−0.35, 0.07) | −0.08 (−0.30, 0.14) |
| 3 (1.07–1.20 for women, 1.18–1.35 for men) | 967 | −0.03 (−0.25, 0.18) | 0.03 (−0.19, 0.25) |
| 4 (≥1.20 for women, ≥1.35 for men) | 966 | −0.28 (−0.51, −0.05) | −0.16 (−0.41, 0.08) |
Values in parentheses are 95% confidence intervals. eGFRcr, estimated GFR by creatinine; eGFRcys, estimated GFR by cystatin C; MESA, Multi-Ethnic Study of Atherosclerosis; eGFR, estimated GFR.
a
Demographic adjusted: adjusted for age, race, and education level.
b
Fully adjusted for above variables plus body mass index, systolic BP, hypertension medications, diabetes, HDL, IL-6, and C-reactive protein.