Table 3.
Association of cardiac concentricity with incident CKDa among MESA participants with baseline eGFRcr ≥60 ml/min per 1.73 m2 by Poisson regression
| Predictor | n | Demographic Adjusted IRRb | Fully Adjusted IRRc |
|---|---|---|---|
| Incident CKD defined by eGFRcr | 457 | ||
| concentricity | |||
| continuous (per SD=0.24) | 3866 | 1.17 (1.09, 1.26) | 1.08 (1.00, 1.18) |
| quartile (g/ml) | |||
| 1 (<0.95 for women, <1.06 for men) | 966 | Reference | Reference |
| 2 (0.95–1.06 for women, 1.06–1.17 for men) | 967 | 1.03 (0.79, 1.35) | 0.99 (0.76, 1.30) |
| 3 (1.07–1.20 for women, 1.18–1.35 for men) | 967 | 1.12 (0.86, 1.44) | 1.07 (0.83, 1.40) |
| 4 (≥1.20 for women, ≥1.35 for men) | 966 | 1.43 (1.12, 1.82) | 1.21 (0.94, 1.56) |
| Incident CKD defined by eGFRcys | 158 | ||
| concentricity | |||
| continuous (per SD=0.24) | 3866 | 1.19 (1.04, 1.35) | 1.16 (1.00, 1.35) |
| quartile (g/ml) | |||
| 1 (<0.95 for women, <1.06 for men) | 966 | Reference | Reference |
| 2 (0.95–1.06 for women, 1.06–1.17 for men) | 967 | 1.17 (0.67, 2.05) | 1.18 (0.64, 2.18) |
| 3 (1.07–1.20 for women, 1.18–1.35 for men) | 967 | 1.44 (0.85, 2.43) | 1.57 (0.88, 2.78) |
| 4 (≥1.20 for women, ≥1.35 for men) | 966 | 1.72 (1.04, 2.82) | 1.63 (0.92, 2.88) |
| Incident CKD defined by both eGFRcr and eGFRcys | 116 | ||
| concentricity | |||
| continuous (per SD=0.24) | 3866 | 1.21 (1.05, 1.40) | 1.20 (1.01, 1.41) |
| quartile (g/ml) | |||
| 1 (<0.95 for women, <1.06 for men) | 966 | Reference | Reference |
| 2 (0.95–1.06 for women, 1.06–1.17 for men) | 967 | 1.38 (0.68, 2.81) | 1.37 (0.64, 2.92) |
| 3 (1.07–1.20 for women, 1.18–1.35 for men) | 967 | 1.98 (1.02, 3.86) | 1.94 (0.94, 4.03) |
| 4 (≥1.20 for women, ≥1.35 for men) | 966 | 2.73 (1.45, 5.14) | 2.23 (1.09, 4.54) |
Values in parentheses are 95% confidence intervals. MESA, Multi-Ethnic Study of Atherosclerosis; eGFRcr, estimated GFR by creatinine; eGFRcys, estimated GFR by cystatin C; IRR, incident rate ratio.
a
Incident CKD defined as eGFR <60 ml/min per 1.73 m2 and a decline in eGFR of >1 ml/min per year.
b
Demographic adjusted for age, race, education level, baseline eGFR (creatinine for creatinine models; cystatin C for cystatin C models; both for third model).
c
Fully adjusted for the above variables plus body mass index, systolic BP, hypertension medications, diabetes, HDL, IL-6, and C-reactive protein.