Table 2.
Phenotype | Genetic background |
% of affected | With septal defect |
Without septal defect |
Type of septal defect |
---|---|---|---|---|---|
Ts65Dn | B6/C3H§ | 4.7% | 2 | 41 | 2 membranous VSD |
Creld1 +/− | B6/C3H‼ | 0 | 0 | 18 | N/A |
B6 | 0 | 0 | 27 | N/A | |
Hey2 +/− | B6/C3H‼ | 0 | 0 | 20 | N/A |
B6 | 0 | 0 | 25 | N/A | |
Ts65Dn, Creld1+/− | B6/C3H§ | 33.3%* | 6 | 12 | 3 membranous VSDs, 3 secundum ASDs |
Ts65Dn, Hey2+/− | B6/C3H§ | 24%† | 6 | 19 | 3 membranous VSDs, 1 muscular VSD, 2 secundum ASDs |
Creld1+/−, Hey2+/− | B6 | 9.7%‡ | 3 | 28 | 3 secundum ASDs |
Hey2−/− | B6 | 78.6% | 11 | 3 | 11 membranous VSDs |
Creld1+/−, Hey2−/− | B6 | 90% | 9 | 1 | 9 membranous VSDs, among those 9, 1 has extra secundum ASD and 1 has extra muscular VSD |
indicates a significant difference between Ts65Dn, Creld1+/− and Ts65Dn (p=0.006) or Creld1+/− (p=0.0003)
significant difference between Ts65Dn, Hey2+/− and Ts65Dn (p=0.04) or Hey2+/− (p=0.0014)
significant difference between Creld1+/−, Hey2+/− and the single mutants (p=0.016).
75% B6, 25% C3H
50% B6, 50% C3H