. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2012 Apr 20;5(3):301–308. doi: 10.1161/CIRCGENETICS.111.960872

Table 2.

Frequency of heart defects on mutant and trisomic genetic backgrounds.

Phenotype	Genetic background	% of affected	With septal defect	Without septal defect	Type of septal defect
Ts65Dn	B6/C3H^§	4.7%	2	41	2 membranous VSD
Creld1 ^+/−	B6/C3H^‼	0	0	18	N/A
Creld1 ^+/−	B6	0	0	27	N/A
Hey2 ^+/−	B6/C3H^‼	0	0	20	N/A
Hey2 ^+/−	B6	0	0	25	N/A
Ts65Dn, Creld1^+/−	B6/C3H^§	33.3%^*	6	12	3 membranous VSDs, 3 secundum ASDs
Ts65Dn, Hey2^+/−	B6/C3H^§	24%^†	6	19	3 membranous VSDs, 1 muscular VSD, 2 secundum ASDs
Creld1^+/−, Hey2^+/−	B6	9.7%^‡	3	28	3 secundum ASDs
Hey2^−/−	B6	78.6%	11	3	11 membranous VSDs
Creld1^+/−, Hey2^−/−	B6	90%	9	1	9 membranous VSDs, among those 9, 1 has extra secundum ASD and 1 has extra muscular VSD

indicates a significant difference between Ts65Dn, Creld1^+/− and Ts65Dn (p=0.006) or Creld1^+/− (p=0.0003)

^†

significant difference between Ts65Dn, Hey2^+/− and Ts65Dn (p=0.04) or Hey2^+/− (p=0.0014)

^‡

significant difference between Creld1^+/−, Hey2^+/− and the single mutants (p=0.016).

^§

75% B6, 25% C3H

^‼

50% B6, 50% C3H