Table 1.

Four SNPs passed the Bonferroni threshold after comparing slow progressors against controls on low frequency SNPs (MAF < 5%). For each SNP, the chromosome, the minor allele A1, the minor allele frequency (MAF), the frequency of the group in the dominant mode (used for association tests), the p value in the dominant mode, the odds ratio (OR), and the genes concerned (SNP and/or SNP(s) in LD with r2≥0.9 in Caucasians HapMap data) are provided. A SNP was assigned to a gene if it was located in the gene or within the 2kb flanking regions.

SNP	chr	A1	A2	MAFSP	MAFCTR	Frequency dominant mode: A1A1 & A1A2		PSP-CTR	OR	Gene(s)/LD
						SPALL	CTRALL
rs2395029	6	C	A	10.19%	3.41%	20.38%	6.81%	8.54×10−15	3.41 CI 95%: 2.4–4.8	HCP5, intergenic, MICB
rs9368699	6	G	A	9.20%	3.48%	18.13%	6.96%	3.03×10−10	2.9 CI 95%: 2.04–4.16	C6orf48, RDBP, TNXB
rs8192591	6	T	C	6.83%	3.15%	13.63%	6.30%	9.08×10−7	2.32 CI 95%: 1.56– 3.41	NOTCH4 GPSM3
rs2072255	17	A	G	4.79%	10.04%	9.04%	18.87%	3.30×10−6	0.43 CI 95%: 0.28–0.63	RICH2