Figure 6. BMT studies.
(A) BW gain and (B) daily food intake of 12-week HFD-fed BMT-WT and BMT-KO mice. (C) GTT (n = 9–11 mice per group). (D) Insulin concentration. (E) ITT. (F–J) Hyperinsulinemic-euglycemic clamp studies in BMT-KO and BMT-WT littermates (n = 5–6 per group). (F) GIR. (G) Basal HGP. (H) HGP suppression by insulin. (I) IS-GDR. (J) Insulin-stimulated FFA suppression. (K) Plasma protein expression of inflammatory markers. q-PCR analysis of inflammatory gene expression in (L) eWAT and (M) liver. *P < 0.05 vs. WT, repeated-measures 2-way ANOVA (A–E) or Student’s t test (F–I).