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. 2012 Jun 1;122(7):2578–2589. doi: 10.1172/JCI62848

Figure 4. Effect of FOXO1 KO in the VMH on leptin administration and fasting.

Figure 4

(A) Changes in body weight after exogenous leptin injection (significant leptin effect [2-way ANOVA, F1.34 = 5.02]). (B) Changes in food intake after exogenous leptin administration. (C) Energy expenditure for individual mice for 12 hours after leptin injection. Symbols represent individual mice. (D) Changes in body weight during fasting and refeeding. (E) Temporal changes of VO2 before and after fasting (significant interaction between genotype and time (2-way ANOVA, F69.1260 = 1.33, P = 0.0381). (F) Food intake for 24 hours during ad libitum or refeeding. Numbers of animals used are expressed in parentheses in each graph. The data are expressed as mean ± SEM (*P < 0.05, Student’s t test).