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. 2012 Jun 25;122(7):2613–2621. doi: 10.1172/JCI63415

Figure 4. Activation kinetics of wild-type and αV188M AChR.

Figure 4

Left: Representative single-channel currents at the indicated ACh concentrations recorded from HEK cells expressing (A) wild-type and (B) αV188M AChRs. Currents are shown as upward deflections; bandwidth, 10 kHz. Center and right: Histograms of closed and open durations corresponding to each ACh concentration are shown with the probability density functions (smooth curves) generated from a global fit of the scheme to dwell times obtained for the entire range of ACh concentrations. Fitted rate constants are shown in Table 2. On the y axes, each histogram entry is the probability of occurrence on a square root (Sqrt) scale.