Figure 3. A model of how GATA1 mutations in DBA favor production of GATA1s alone.

(A) Normal splicing pattern of GATA1 in humans and the resulting mRNA and protein products. (B) Aberrant splicing of exons 2 and 3 (highlighted by red star at mutation sites) leads to production of GATA1s alone. For the protein products, the transactivation domain (TD), N-terminal zinc finger (NF), and C-terminal zinc finger (CF) are shown.