Table 3.
Interaction between CSA-13 and different host antibacterial agents assessed with fractional inhibitory concentration (FIC) index. FICindex was interpreted as follows: <0·5 (synergy; S), 0·5–0·75 (partial synergy; PS), 0·76–1·0 (additive effect; AE), >1·0–4·0 (indifference; I), >4·0 (antagonism, A)
| Bacterial strain | FIC | CSA-13 with
|
Interpretation 1/2/3/4 | |||
|---|---|---|---|---|---|---|
| 1 LL-37 |
2 lysozyme |
3 lactoferrin |
4 sPLA |
|||
| Pseudomonas aeruginosa Xen 5 | FICA/FICB | 0·368/0·308 | 0·387/0·572 | 0·574/0·574 | 0·472/0·449 | PS/AE/I/AE |
| FIC index | 0·676 | 0·959 | 1·148 | 0·921 | ||
| Staphylococcus aureus ATCC 43300 | FICA/FICB | 0·1/0·163 | 0·104/0·305 | 0·328/0·515 | 0·238/0·469 | S/S/PS/PS |
| FIC index | 0·263 | 0·409 | 0·843 | 0·707 | ||
| Helicobacter pylori | FICA/FICB | 0·465/0·168 | 0·48/0·371 | 0·371/0·379 | 0·304/0·093 | PS/AE/PS/S |
| FIC index | 0·633 | 0·851 | 0·750 | 0·397 | ||