Table 2.

Examples of immune effects by histamine receptor-2 antagonists

Agent	Cell/whole animal	Response	Reference
Cimetidine	Guinea pigs	Increases activity of delayed type hypersensitivity and experimental autoimmune encephalomyelitis incidence	[25]
Cimetidine	Mouse T cells	Inhibits induction of T suppressor cells	[45]
Cimetidine	Mouse splenocytes	Increases antibody production, and proliferation of mitogen-activated splenocytes in response to tetanus toxoid	[51]
Cimetidine	Mouse T cells	Inhibits regulatory T cell-like activity	[49]
Cimetidine	Human T cells	Reduces suppressor T cell response	[46]
Cimetidine	Human lymphocytes	Increases the mitogen-activated T cell response	[42,43]
Cimetidine	Human DCs	Increases the capacity of antigen presentation by DCs from immunosuppressed cancer patients	[75]
Ranitidine	Human T cells	Increases CD4+ T cells and mitogen-stimulated IFN-γ production from patients with head injury	[52]
Ranitidine	Human monocytes, neutrophils, natural killer cells, delayed type hypersensitivity	Reverses surgery-induced immune suppression	[54,55]

DC: dendritic cell; IFN-γ: interferon gamma.