Table 1. SAXS analysis of eAPP fragments and their complexes.
Protein | Peptide | Dmax (Å) | Rg (Å) | MWcalc/MWseq |
TRX-eAPP290–624 | -na- | 150 | 41 | 2.0 |
TRX-eAPP290–624 | Aβ11-17 | 130 | 38 | 1.2 |
TRX-eAPP290–624 | Aβ 1-28 | 140 | 42 | 1.5 |
TRX-eAPP290–624 | APP319-335 | 140 | 41 | 1.3 |
TRX-eAPP290–624 | 7-kDa Aβ1-40 | 160 | 40 | 1.1 |
TRX-eAPP290–624 | 20-kDa Aβ1-42 | 160 | 43 | 2.5 |
eAPP230–624 | -na- | 150 | 44 | 2.0 |
eAPP230–624 | RERMS | 130 | 39 | 1.8 |
eAPP230–624 | Aβ 1-28 | 170 | 46 | 0.9 |
eAPP230–624 | 7-kDa Aβ1-40 | 180 | 49 | 1.2 |
eAPP230–624 | 20-kDa Aβ1-42 | 170 | 46 | 2.6 |
MBP-eAPP230–624 | -na- | 190 | 55 | 2.0 |
MBP-eAPP230–624 | 2% DMSO | 180 | 54 | 2.0 |
MBP-eAPP230–624 | 1,8-ANS | 190 | 63 | 1.9 |
MBP-eAPP230–624 | Sulfiram | 170 | 53 | 1.7 |
MBP-eAPP230–624 | Disulfiram | 160 | 51 | 1.5 |
MBP-eAPP230–624 | Aβ10-20 | 160 | 51 | 1.3 |
MBP-eAPP230–624 | Aβ5-14 | 180 | 54 | 1.6 |
MBP-eAPP230–624 | Aβ12-24 | 180 | 54 | 1.8 |
MBP-eAPP230–624 | Aβ1-28 | 180 | 54 | 1.2 |
MBP-eAPP230–624 | 7-kDa Aβ1-40 | 210 | 63 | 1.1 |
MBP-eAPP230–624 | 20-kDa Aβ1-42 | 210 | 58 | 2.2 |