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. 2012 Jun 29;7(6):e40348. doi: 10.1371/journal.pone.0040348

Figure 1. AM and MDM share common gene expression characteristics.

Figure 1

(A) AM cultured for 24 hours exhibit similar appearances to MDM (differentiated for seven days) on light microscopy. (B) Mean relative gene expression levels of selected macrophage characteristic genes are comparable in AM (from four donors) and MDM (from eight donors). Many of these genes are also expressed in monocytes (from four donors), and to a lesser extent in DC (from five donors), but not in any of the cell lines. (C) Hierarchical clustering on the basis of macrophage signature genes also shows that AM and MDM transcriptional profiles are closely related, and segregate together with other myeloid cells, distinct from undifferentiated THP1, HeLa and SUPT1 cells and a standard reference RNA sample.