Skip to main content
. 2012 Jun 29;7(6):e40191. doi: 10.1371/journal.pone.0040191

Figure 3. Reduced ARC NPY expression and increased body weight in young Y1Y5−/− mice on chow.

Figure 3

(A–B) Bright field photomicrographs of coronal brain sections from 15 week old male wildtype control (WT, A) and germline Y1Y5 receptor knockout (Y1Y5−/−, B) mice after in situ hybridisation for NPY mRNA. Scale bar  = 25 µm. Abbreviations: 3V; third ventricle, ARC, arcuate nucleus of the hypothalamus. (C–D) Body weight from 5 to 15 weeks of age in male (C) and 5 to 13 weeks of age in female (D) WT or Y1Y5−/− mice. Plotted values are means ± SEM of 4–21 standard chow-fed mice per group. ***P<0.001 for Y1Y5−/− versus WT mice of the same age and sex.