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. 2012 Jun 29;7(6):e40191. doi: 10.1371/journal.pone.0040191

Figure 4. Altered energy expenditure and decreased respiratory exchange ratio in Y1Y5−/− mice on chow.

Figure 4

(A–L) 24-hour time course of energy expenditure (A–D), physical activity (E–H) and respiratory exchange ratio (I–L) in male and female germline Y1Y5 receptor knockout (Y1Y5−/−) or wildtype control (WT) mice at 20 and 36 weeks of age. Energy expenditure was adjusted for lean mass by analysis of covariance (ANCOVA). Adjusted energy expenditure was presented at a common lean mass of 21.936 g (males) and 16.015 g (females) at 20 weeks of age and 23.172 g (males) and 17.115 g (females) at 36 weeks of age. Open and filled horizontal bars indicate light and dark phases, respectively. Plotted values are means ± SEM of 5–12 standard chow-fed mice per group. *P<0.05, **P<0.01, or ***P<0.001 for Y1Y5−/− versus WT mice of the same age and sex.