Figure 8. Effect of adult-onset hypothalamus-specific Y1Y5 receptor deletion on weight regain after a 24-hour fast.

Body weight measurements were taken at the time points of fasting-induced food intake measurements in male (A, C, E, G) and female (B, D, F, H) adult-onset hypothalamus-specific Y1Y5 receptor knockout (Y1Y5^Hyp/Hyp) or control (Y1Y5^lox/lox) mice, at both 17 and 34 weeks of age and on a standard chow (Chow) or a high fat diet (HFD). Data are represented as a percent of pre-fasting body weight (%basal). Absolute pre-fasting body weights at 17 weeks of age were Y1Y5^lox/lox male  = 25.4±0.6 g (standard chow), 28.0±0.6 g (HFD); Y1Y5^−/− male  = 26.1±0.9 g (standard chow), 28.9±0.9 g (HFD); Y1Y5^lox/lox female  = 20.1±0.5 g (standard chow), 21.6±1.0 g (HFD); Y1Y5^−/− female  = 20.1±0.6 g (standard chow), 21.6±0.8 g (HFD), and at 34 weeks of age were Y1Y5^lox/lox male  = 30.0±1.3 g (standard chow), 34.0±1.5 g (HFD); Y1Y5^−/− male  = 31.2±1.6 g (standard chow), 40.2±1.6 g (HFD); Y1Y5^lox/lox female  = 24.7±0.7 g (standard chow), 27.9±1.5 g (HFD); Y1Y5^−/− female  = 27.1±2.0 g (standard chow), 29.9±1.3 g (HFD). Plotted values are means ± SEM of 4–21 mice per group. *P<0.05 for Y1Y5^Hyp/Hyp versus Y1Y5^lox/lox mice of the same age, sex and diet.