Table 2. Hemodynamic and echocardiographic data at 4 and 15 wk rats.
| 4 wk Sham | 4 wk ACF | 15 wkSham | 15 wkACF | |
| (n = 8) | (n = 8) | (n = 10) | (n = 10) | |
| HR (beats/min) | 260±12 | 271±11 | 217±12† | 220±5 |
| MAP (mmHg) | 114±4 | 95±3* | 95±4†† | 82±4* |
| LVEDP (mmHg) | 2±1 | 7±1* | 5±1 | 9±1* |
| LV+dP/dt (mmHg/sec) | 8031±440 | 8947±745 | 7529±445 | 6600±289 |
| LV-dP/dt (mmHg/sec) | −7479±337 | −6995±458 | −5401±358† | −4244±222* |
| LVEDD (mm) | 7.0±0.2 | 10.1±0.3* | 9.0±0.1† | 11.6±0.4* |
| LVESD (mm) | 4.3±0.3 | 6.3±0.3* | 5.6±0.1† | 7.4±0.3* |
| LVEDD/PW | 4.8±0.3 | 7.7±0.5* | 5.9±0.3 | 7.9±0.4* |
| LVED-WS (g/cm2) | 3±1 | 14±3** | 7±1† | 16±1* |
| LVES-WS (g/cm2) | 67±13 | 77±8 | 72±7 | 80±6 |
| LVFS (%) | 38±4 | 38±2 | 40±1 | 34±2* |
Values are expressed as mean±SEM. In each group, values in parentheses represent n. *P<0.05, **P<0.01 vs. age-matched shams. † P<0.05, †† P<0.01 vs. 4 wk shams. ACF: aortocaval fistula; HR: heart rate; MAP: mean arterial pressure; LVEDP: LV end-diastolic pressure; LV+dP/dt: LV pressure derivative maximum; LV-dP/dt: LV pressure derivative minimum. LVEDD: LV end-diastolic dimension; LVESD: LV end-systolic dimension; LVEDD/PW: LV end-diastolic dimension to posterior wall thickness ratio; LVED-WS: LV end-diastolic wall stress; LVES-WS: LV end-systolic wall stress; LV FS: LV fractional shortening.