Table 4. Effect of aprotinin on hemodynamics and LV remodeling at 2 day and 4 wk rats.
| 2 day | 4 wk | |||||||
| Sham(n = 5) | ACF(n = 5) | Sham+Apr(n = 5) | ACF+Apr(n = 5) | Sham(n = 7) | ACF(n = 8) | Sham+Apr(n = 7) | ACF+Apr(n = 8) | |
| HR (beats/min) | 359±6 | 367±8 | 371±4 | 375±12 | 321±7 | 307±3 | 312±5 | 316±3 |
| MAP (mmHg) | 100±2 | 89±3 | 106±1 | 84±5* | 107±3 | 90±2* | 106±5 | 86±2* |
| LVEDP (mmHg) | 6±1 | 11±1 | 5±1 | 11±2* | 4±0 | 10±1* | 4±1 | 10±1* |
| LVESP (mmHg) | 55±3 | 61±3 | 58±2 | 57±4 | 85±3 | 75±2 | 86±5 | 70±3* |
| LV+dP/dt (mmHg/s) | 8767±391 | 9386±260 | 8301±442 | 9065±354 | 8505±450 | 8116±348 | 7931±415 | 8937±423 |
| LV-dP/dt (mmHg/s) | −7474±152 | −8797±411 | −8474±123 | −7879±530 | −7379±445 | −5948±131* | −7422±236 | −6834±333 |
| LVEDD (mm) | 6.9±0.2 | 8.2±0.2* | 7.0±0.1 | 8.0±0.1* | 7.7±0.2 | 10.6±0.3* | 7.6±0.1 | 10.2±0.2* |
| LVESD (mm) | 4.0±0.2 | 4.3±0.5 | 4.1±0.2 | 4.0±0.2 | 4.7±0.2 | 6.8±0.3* | 4.7±0.2 | 5.9±0.2*† |
| LVEDD/PW | 4.6±0.2 | 5.8±0.2* | 4.6±0.3 | 5.4±0.4 | 4.2±0.2 | 5.7±0.3* | 4.5±0.4 | 6.0±0.4* |
| LV FS (%) | 41±2 | 48±5 | 43±2 | 50±3 | 38±2 | 37±1 | 39±1 | 43±1† |
| LV EF (%) | 66±3 | 76±5 | 72±2 | 79±3 | 66±2 | 63±2 | 67±2 | 71±1† |
| VCFr (%) | 8.3±0.6 | 10.2±0.5 | 9.8±0.8 | 10.1±0.6 | 7.9±0.8 | 5.7±0.2 | 7.5±0.5 | 7.4±0.6 |
| LVED-WS (g/cm2) | 4±1 | 16±1* | 6±1 | 16±4* | 4±1 | 15±2* | 4±1 | 16±2* |
| LVES-WS (g/cm2) | 50±3 | 54±3 | 49±9 | 37±7 | 65±5 | 81±8 | 68±8 | 62±6 |
| Coll Vol (%) | 3.9±0.2 | 2.1±0.1* | 4.0±0.3 | 3.6±0.2† | 3.5±0.1 | 2.4±0.1* | 3.5±0.1 | 3.2±0.1† |
Values are expressed as mean±SEM. In each group, values in parentheses represent n. *P<0.05 vs. age-matched shams. † P<0.05 vs. ACF. ACF: aortocaval fistula; Apr: aprotinin; HR: heart rate; MAP: mean arterial pressure; LVEDP: LV end-diastolic pressure; LV+dP/dt: LV pressure derivative maximum; LV-dP/dt: LV pressure derivative minimum. LVEDD: LV end-diastolic dimension; LVESD: LV end-systolic dimension; LVEDD/PW: LV end-diastolic dimension to posterior wall thickness ratio; FS: fractional shortening; EF: ejection fraction; VCFr: velocity of circumferential fiber shortening; LVED-WS: LV end-diastolic wall stress; LVES-WS: LV end-systolic wall stress; Coll Vol (%): interstitial collagen volume percent.