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Effect of SGMI-1 and SGMI-2 on the autoactivation of isolated MASP-2. The time course of autoactivation of isolated zymogen catalytic fragment of MASP-2 was studied in the presence or absence of inhibitors. At 1-μM inhibitor concentration, the MASP-2–specific SGMI-2 (▲) completely inhibited the autoactivation process, and the MASP-1–specific SGMI-1 (■) had no effect at all compared with the noninhibited sample (●).
