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. 2012 May 22;109(26):E1782–E1790. doi: 10.1073/pnas.1120534109

Fig. 2.

Fig. 2.

The binding specificity of P. falciparum-IEs changed after selection on HBMECs. (A) The initial and HBMEC-panned parasite lines were compared for binding to CHO cells that differed in CSA, CD36, ICAM-1, VCAM-1, or ELAM-1 surface expression. (B) The initial and HBMEC-panned parasite lines were compared for binding to recombinant proteins. (C) The ability of anti-CD36 or anti-ICAM-1 antibodies to block IE binding to primary HBMECs (donor 13) was compared between the initial and HBMEC-panned parasite lines. Percentage of inhibition (%) is indicated between bars. Binding results in A–C are expressed as means ± SDs from two to three independent experiments.