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. 2012 Jun 29;7(6):e39302. doi: 10.1371/journal.pone.0039302

Figure 2. Flow diagrams of the experimental design regarding times and type of treatment and EEG recording.

Figure 2

After Exp. #2 (A) the proportion of rats that achieved full kindling status reached 80% (C; p = 0.001). By comparison, 31% of rats administered a subconvulsive dose of PTZ at all times (Exp. #3)(B) reached full kindling status after two injections and up to 81% of animals reached full kindling status after the fourth treatment (C; p = 0.001). (D–F): A subconvulsive PTZ treatment elicited intermittent non-ictal events that are typically dependent on the behavioral state of the animal (active or passive wakefulness)(D). After the second PTZ injection, the animals usually demonstrated mild multifocal body jerks (E). After the third PTZ injection, the animals showed typical seizure activity associated with motor arrest (F).