Table 4. Brain regions mediating association between psychological measurement and age.

		MNI				Cluster
Anatomical region	BA	x	y	z	T	k
Neuroticism-Age
no mediation
Extraversion-Age
Positive correlation with age
Insula	13	−40	−10	20	4.55	32
Middle temporal gyrus	22	−58	−34	−2	4.45	23
Precuneus	19	36	−74	36	4.27	19
Negative correlation with age
no mediation
Anxiety-Age
Positive correlation with age
no mediation
Negative correlation with age
Angular gyrus/Supramarginal gyrus		40	−62	34	4.39	23
Precentral gyrus	6	16	−20	64	4.23	18
Red nucleus, Substantia nigra		8	−22	−8	4.14	16
Depression-Age
no mediation

Statistical threshold: p<0.001 uncorrected, k = 10.

MNI refers to Montreal Neurological Institute coordinates; BA refers to putative Brodmann Area; L and R refer to left and right hemispheres.