Table 1. Characteristics of the study population.
female | male | p | NGTa | IFGb | pc | IGTd | pc | IFG+IGTe | pc | |
959 | 483 | 1046 | 142 | 140 | 114 | |||||
age (years) | 39.2±12.9 | 40.2±13.4 | 0.26 | 37.5±12.4 | 43.4±13.0 | <0.0001 | 42.1±13.2 | <0.0001 | 49.7±13.3 | <0.0001 |
BMI (kg/m2) | 28.7±8.1 | 28.1±7.3 | 0.66 | 27.2±6.8 | 32.7±10.8 | <0.0001 | 29.7±7.3 | <0.0001 | 33.8±9.6 | <0.0001 |
family history of diabetes | 48.5% | 49.0% | 0.77 | 45.8% | 58.5% | 0.006 | 60.4% | 0.002 | 52.7% | 0.19 |
systolic blood pressure (mmHg) | 121±17 | 126±16 | <0.0001 | 119±15 | 128±16 | <0.0001 | 128±16 | <0.0001 | 134.0±18.9 | <0.0001 |
diastolic blood pressure (mmHg) | 75±11 | 77±11 | 0.07 | 74±10 | 78±11 | 0.002 | 79±12 | <0.0001 | 81.6±10.5 | <0.0001 |
Fasting glucose (mmol/l) | 5.1±0.5 | 5.2±0.6 | 0.001 | 4.9±0.4 | 5.9±0.3 | <0.0001 | 5.1±0.3 | <0.0001 | 6.1±0.3 | <0.0001 |
2-hour glucose (mmol/l) | 6.4±1.6 | 6.1±1.7 | 0.001 | 5.6±1.1 | 6.2±1.0 | <0.0001 | 8.7±0.8 | <0.0001 | 9.2±1.0 | <0.0001 |
Fasting insulin (pmol/l) | 64±54 | 58±47 | 0.005 | 54±43 | 83±72 | <0.0001 | 71±52 | <0.0001 | 102.4±64.0 | <0.0001 |
2-hour insulin (pmol/l) | 453±463 | 376±412 | <0.0001 | 330±299 | 424±345 | <0.0001 | 745±580 | <0.0001 | 928±835 | <0.0001 |
HOMA-ß (AU) | 139±139 | 117±86 | 0.001 | 131±134 | 117±104 | 0.015 | 151±103 | 0.004 | 133±76 | 0.20 |
HOMA-IR (AU) | 2.5±2.2 | 2.3±2.1 | 0.001 | 2.0±1.6 | 3.6±3.2 | <0.0001 | 2.7±2.0 | <0.0001 | 4.6±3.1 | <0.0001 |
TG (mmol/l) | 1.2±0.8 | 1.9±2.8 | <0.0001 | 1.3±1.7 | 1.5±1.7 | 0.004 | 1.8±2.1 | <0.0001 | 1.8±1.4 | <0.0001 |
Cholesterin (mmol/l) | 5.0±0.9 | 5.0±1.1 | 0.45 | 5.0±1.0 | 5.0±0.9 | 0.89 | 5.2±1.0 | 0.022 | 5.1±0.9 | 0.044 |
HDL (mmol/l) | 1.5±0.4 | 1.2±0.3 | <0.0001 | 1.4±0.4 | 1.3±0.3 | 0.001 | 1.4±0.3 | 0.008 | 1.3±0.3 | 0.001 |
LDL (mmol/l) | 3.0±0.8 | 3.2±0.8 | 0.0003 | 3.0±0.8 | 3.1±0.8 | 0.24 | 3.2±0.8 | 0.006 | 3.2±0.8 | 0.020 |
lipid lowering therapy | 4.3% | 2.4% | 0.0007 | 1.1% | 4.9% | 0.003 | 5.7% | 0.001 | 7.0% | 0.0002 |
antihypertensive therapy | 9.5% | 7.9% | 0.12 | 4.8% | 12.7% | 0.0007 | 10.7% | 0.009 | 27.2% | <0.0001 |
Data are means ± standard deviations.
normal glucose tolerance.
isolated impaired fasting glycemia.
as compared to normal glucose tolerance.
isolated impaired glucose tolerance.
concomitant impaired fasting glycemia and impaired glucose tolerance.