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. 2012 Jun 29;7(6):e39897. doi: 10.1371/journal.pone.0039897

Figure 1. Intrathecal injection of spironolactone (Spir) improves pain behaviors after CCD surgery (n = 6/each).

Figure 1

D0, 1, 4, 7, 10, 14, 17 and 21 indicate days of CCD. All data points represent mean±SD. Compared with sham group, chronic compression of the dorsal root ganglion (CCD) significantly decreased paw withdraw mechanical threshold (PWMT) (A) and thermal latency (PWTL) (B), * P<0.01. Both mechanical allodynia (A) and thermal hyperalgesia (B) were diminished in CCD rats treated with spironolactone (3 µg), minocycline (0.11 mg) and spironolactone (3 µg) with half-hour pre-application minocycline (0.11 mg) twice a day from Days 2 to 4 subsequent to CCD surgery, # P<0.01.