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. 2012 Jun 29;7(6):e38864. doi: 10.1371/journal.pone.0038864

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Two upper panels: Left - comprising residues (77–470) and right (674–1254) built using comparative modeling (3D-PSSM algorithm). Bottom panel ADAMTS13 X-ray structure residues (287–682) PDB ID 3GHM. Helices are depicted in red and beta-structures are in yellow. Residues encoded by codons/variants under investigation are denoted with residue number (van der Waals’ radii of the side chains are shown). Beginning and end of each fragment are also denoted with a residue number.