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. 2012 Jun 29;7(6):e38870. doi: 10.1371/journal.pone.0038870

Table 1. Radio-responsive biomarkers identified by literature review and their biological processes.

Gene Symbol Entrez Gene ID DNA repair Cell proliferation Cell cycle Apoptosis Response to stress Reference
ABCA1 19 [14]
ABL1 25 v v v v [4]
ACTA2 59 [15]
AEN 64782 v v [16]
AKR1B1 231 v [17]
AKT1 207 v v v [18]
ALAD 210 [19], [20]
ANXA1 301 v v v v [21]
APEX1 328 v v [22]–[26]
APOE 348 v v v [27]
AR 367 v [4]
ATF3 467 v [28]
ATM 472 v v v v v [25], [26], [29]–[43]
BAD 572 v v [44]
BAK1 578 v [45]
BAX 581 v [37], [44]–[47]
BAZ1B 9031 v v [17]
BBC3 27113 v [16], [48]–[50]
BCL2 596 v v v v [37], [44], [46], [51], [52]
BCL2L1 598 v v v [51]
BIRC5 332 v v [53]
BRCA1 672 v v v v v [54]–[59]
BRCA2 675 v v v v v [54]–[57], [59], [60]
BTG2 7832 v v v v [61]
CAT 847 v v [62]
CAV1 857 v v [63]
CCNB1 891 v v v [48]
CCND1 595 v v v [46]
CCNE1 898 v [61]
CCNG1 900 v v v [49]
CD24 100133941 v v v [21]
CD40 958 v v [64]
CD68 968 [20]
CD69 969 [16]
CD70 970 v v [65]
CD83 9308 v [21]
CDC20 991 v v [66]
CDC6 990 v v [61]
CDH2 1000 [21]
CDK1 983 v v v v [4], [61]
CDK2 1017 v v [61]
CDKN1A 1026 v v v v [15], [16], [37], [47]–[50], [61], [67], [68]
CDKN2A 1029 v v v v [69]
CHEK1 1111 v v v v [70], [71]
CLIC1 1192 [72]
CRYAB 1410 v v [21]
CSNK2A2 1459 v [73]
CXCR4 7852 v v [15]
CYP2D6 1565 [74]
DCN 1634 v [21]
DDB2 1643 v v [15], [21]
DDR1 780 [15]
DDR2 4921 v [15]
DDX17 10521 [17]
DRAP1 10589 [17]
DUSP8 1850 [16]
EGFR 1956 v v v v [46]
EGR1 1958 v [16]
EGR4 1961 v [16]
EI24 9538 v [47]
EIF2AK3 9451 v v [75]
EPDR1 54749 [20]
ERBB2 2064 v v v [46], [76]–[78]
ERCC1 2067 v v [52]
ERCC2 2068 v v v v v [36], [74]
ERCC4 2072 v v v [52], [79]
ERCC5 2073 v v v [52]
FAS 355 v [47], [80]
FASLG 356 v v v [80]
FDXR 2232 [49], [50], [68]
FGF1 2246 v v [81]
FGF2 2247 v v v v [81]
GADD45A 1647 v v v v [15], [16], [48], [49], [61], [67]
GBP1 2633 [21]
GDF15 9518 [15], [82]
GFER 2671 v [83]
GRAP 10750 [16]
GSTA1 2938 [62]
GSTM1 2944 [62], [84]
GSTP1 2950 v [36], [62], [85], [86]
GSTT1 2952 [62], [84]
H2AFX 3014 v v v [41], [87], [88]
HDAC1 3065 v v v [4], [89]
HERC2 8924 v v v [90]
HSP90AB1 3326 v [91]
HSP90B1 7184 v v [82]
HSPB1 3315 v v [91], [92]
HUS1 3364 v v v [93]
ICAM2 3384 [94]
ID3 3399 v v v [20]
IER5 51278 [95]
IFNG 3458 v v v v [16]
IGF1R 3480 v v [46], [96]
IGFBP3 3486 v v [21]
IL12RB2 3595 v [14]
IL17A 3605 v v [97]
ILK 3611 v v v [98]
IRF1 3659 [4]
JUN 3725 v v v v [4], [16]
KRAS 3845 [99]
LIG1 3978 v v v [20]
LIG3 3980 v v v [19], [20]
LIG4 3981 v v v v v [35], [60], [74], [100]
LOX 4015 v [21]
LSM7 51690 [17]
MAD2L2 10459 v [19]
MAP3K7 6885 v v [19], [20]
MC1R 4157 v v v [101]
MCL1 4170 v [102]
MCM2 4171 v [61]
MDC1 9656 v v v [35]
MDM2 4193 v v v [16], [49], [52], [103]
MGMT 4255 v v v [20]
MLH1 4292 v v v v [46], [74]
MMP2 4313 v [104]
MMP9 4318 v [105]
MPO 4353 v v [62], [106]
MR1 3140 [15]
MRE11A 4361 v v v [29]
MRPL23 6150 [17]
MSH2 4436 v v v v [46]
MTHFR 4524 [107]
MTOR 2475 v v [45]
MYC 4609 v v v [108]
NBN 4683 v v v v [29], [109]
NEIL1 79661 v v [110]
NEK2 4751 v [111]
NFKB1 4790 v v [112]
NNMT 4837 [91]
NONO 4841 v v [113]
NOS3 4846 v v v [62], [106]
NOX4 50507 v v [114]
NUDT1 4521 v v [17]
OGG1 4968 v v [115]
PAH 5053 [20]
PAK6 56924 [116]
PARP1 142 v v [70], [117]
PCNA 5111 v v v [16], [118]
PER3 8863 [20]
PHLPP2 23035 [119]
PHPT1 29085 [50]
PIK3CA 5290 v [120]
PIM2 11040 v v v [52]
PLK2 10769 v [16]
PLK3 1263 [61]
PMS2 5395 v v v [46]
POLB 5423 v v v [121]
POLQ 10721 v v [60]
PPA1 5464 [111], [119]
PPM1D 8493 v v [15], [122]
PRDX1 5052 v v v [116]
PRDX4 10549 [123]
PRKCB 5579 v [4]
PRKCZ 5590 v v [52]
PRKDC 5591 v v v [124]–[126]
PROCR 10544 v [21]
PROM1 8842 [127]
PSMB4 5692 v v [17]
PSMD1 5707 v [17]
PTCH1 5727 v [128]
PTEN 5728 v v v [129]
PTGS2 5743 v v v v [46]
PTTG1 9232 v v v [19], [130]
RAD21 5885 v v v v [30], [31], [43], [131]
RAD23B 5887 v v [17]
RAD50 10111 v v v [29], [132]
RAD51 5888 v v v [133]
RAD54L 8438 v v v [134]
RAD9A 5883 v v v v [19], [52]
RALBP1 10928 [135], [136]
RELA 5970 v v v [4], [112]
RND1 27289 [16]
RRM2 6241 [137]
RRM2B 50484 v v v [138]
S100A11 6282 v [15]
SAG 6295 [139]
SART1 9092 v v [20]
SEC22B 9554 [17]
SEPHS1 22929 [140]
SERPINA3 12 v [20]
SERPINE1 5054 v v v [141]
SESN1 27244 v v v [49], [50]
SIRT1 23411 v v v v [142]
SMPD1 6609 v [81]
SOD1 6647 v v v [143]
SOD2 6648 v v v [25], [26], [30], [31], [36], [62], [144], [145]
SRC 6714 [146]
SRF 6722 v [17]
STAT1 6772 v v v [4], [147]
STAT3 6774 v [148], [149]
SUMO1 7341 v v [4]
TGFB1 7040 v v v v [25], [26], [30], [36], [43], [145], [150]–[154]
TNF 7124 v v v v [155]
TNFRSF10B 8795 v [47]
TNFRSF1A 7132 v v [112]
TNFSF10 8743 v [156]
TNFSF9 8744 v v [16]
TOB1 10140 v [157]
TOP2A 7153 v v v [158]
TOR1AIP1 26092 [16]
TP53 7157 v v v v v [37], [41], [46], [48]
TP63 8626 v v v v [159]
TPP2 7174 [160]
TRAF2 7186 v v [161]
TRAF4 9618 v v [16]
TXN 7295 v [162]
TXNRD1 7296 v [163]
UBB 7314 v v [17]
UHRF1 29128 v v v v [164]
UIMC1 51720 v v v [165]
VEGFA 7422 v v v [46], [166]
WRN 7486 v v v [110]
WT1 7490 v v [167]
XIAP 331 v v [49], [168], [169]
XPC 7508 v v v [124], [170]
XRCC1 7515 v v [22,23,25,26,30,31,36,43,115,
144,145,150,154,171–175]
XRCC2 7516 v v v v [109]
XRCC3 7517 v v [25,26,30,31,74,109,115,134,
144,145,172,174–176]
XRCC4 7518 v v v v [164]
XRCC5 7520 v v v v [52], [60], [172], [177]–[179]
XRCC6 2547 v v [20], [176], [178], [180], [181]
DNA-PK [52], [182]
HSP70 [183]
MRN(95) [184]
RAS [185]