Table 2. Pathways and Functions Analysis by IPA.

PATHWAYS	p-value	ratio	enrichment index
Insulin Receptor Signaling	0.002	11/139	263
Integrin Signaling	0.003	14/209	223
FAK Signaling	0.02	7/102	345
PI3K/AKT Signaling	0.03	8/140	285
RAR Activation	0.03	10/183	275
TGF-β Signaling	0.04	6/89	478
FUNCTIONS	p-value	ratio	enrichment index
Skeletal and Muscular System Development and Function	7.8E−06	50/2849	15
Skeletal and Muscular Disorders	2.7E−04	142/3851	11
Neurological Disease	2.4E−04	179/4743	9
Cardiovascular Disease	9.4E−04	110/2663	159
Metabolic Disease	9.4E−04	124/2496	17
Endocrine System Disorders	1.4E−03	10/2271	19
Cell Growth and Proliferation	2.1E−03	36/2884	15
Cardiovascular System Development and Function	2.7E−03	11/2738	15
Ophthalmic Disease	2.7E−03	3/987	43
TOXIC FUNCTIONS	p-value	ratio	enrichment index
Cardiac Damage	3.0E−02	1/88	481
Cardiac Dilation	3.0E−02	4/83	510
Heart Failure	4.8E−02	11/330	128

Table legend:

ratio = number of modulated genes/total number of genes present in the relevant IPA category.

enrichment index =  ratio between observed genes and number of genes expected by chance in each category.