Figure 2.

CAT mouse features microphthalmia and congenital cataracts resulting from a mutation in the gene encoding lens AQP0 (major intrinsic protein of lens). (A) Head of a 3-week-old CAT mouse, revealing the unusually small eye. (B) Lens from a normal 21-day-old mouse. (C) Lens from a 21-day-old CAT mouse is small and contains a dense opacity. Figure provided by Alan Shiels, Washington University, St. Louis, MO.