Table 2. Top canonical pathways represented by proteins differentially regulated in rapid progressor patients.
| Top Canonical Pathwaysa | P Value |
|---|---|
| Lower Expression in Rapid Progressors | |
| 1. Aryl Hydrocarbon Receptor Signaling | 1.80E-04 |
| 2. Glutathione Metabolism | 7.29E-04 |
| 3. Metabolism of Xenobiotics by Cytochrome P450 | 1.12E-03 |
| 4. NRF2-mediated Oxidative Stress Response | 2.25E-03 |
| 5. Xenobiotic Metabolism Signaling | 5.27E-03 |
| Higher Expression in Progressors | |
| 1. CTLA4 Signaling in Cytotoxic T Lymphocytes | 1.27E-03 |
| 2. Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells | 1.35E-03 |
| 2. Allograft Rejection Signaling | 1.35E-03 |
| 3. OX40 Signaling Pathway | 1.35E-03 |
| 5. Graft-vs-Host Disease Signaling | 2.43E-03 |
a
Canonical pathways represent well-established signaling or disease pathways in IPA. Ranking of pathways within each group was based on an FDR-adjusted P value determined by IPA. A summary report containing the proteins mapped to each canonical pathway is provided in Supplemental Table S3.