Table 6.
Comparison of outcomes between Unexposed and E-only MHT participants who were 55 years and younger at study entry
| Outcome | No. of participants (annualized %) | Unadjusted HR (95% CI) |
Adjusted HR (95% CI)* |
|
|---|---|---|---|---|
| E-only MHT (n=434) |
E-only unexposed (n=515) |
|||
| Follow-up time, mean (range), mo | 114.9 (7.9–126.9) | 113.5 (0.75–126.9) | NA | NA |
| Acute MI | 0 (0) | 2 (0.04) | - | - |
| CHD Death | 0 (0) | 0 (0) | - | - |
| Breast cancer | 21 (0.51) | 13 (0.0.26) | 1.91 (0.96–3.82) | 1.85 (0.92–3.73) |
| Stroke | 17 (0.41) | 18 (0.37) | 1.11 (0.57–2.16) | 0.99 (0.50–1.95) |
| CABG/PTCA | 1 (0.02) | 4 (0.08) | 0.29 (0.03–2.64) | 0.18 (0.02–1.89) |
| PE | 2 (0.05) | 0 (0) | - | - |
| DVT | 6 (0.14) | 0 (0) | - | - |
| Colon cancer | 3 (0.07) | 2 (0.04) | 1.78 (0.30–10.6) | 1.81 (0.29–11.2) |
| Endometrial cancer | 2 (0.04) | 3 (0.06) | 0.78 (0.13–4.69) | 0.71 (0.11–4.54) |
| Any cancer | 86 (2.33) | 52 (1.12) | 2.06 (1.46–2.91) | 2.11 (1.49–3.00) |
| Vertebral and hip fractures | 3 (0.07) | 6 (0.12) | 0.58 (0.14–2.32) | 0.58 (0.14–2.38) |
| Any fracture | 15 (0.37) | 26 (0.54) | 0.67 (0.36–1.27) | 0.62 (0.32–1.19) |
| Death | 12 (0.29) | 15 (0.31) | 0.94 (0.44–2.01) | 0.97 (0.45–2.10) |
| Global Index | 53 (1.3) | 53 (1.1) | 1.19 (0.81–1.74) | 1.12 (0.77–1.66) |
*
Adjusted for age, statin use, aspirin use, hypercholesterolemia, diabetes medication use, hypertension