Table 8.
As-treated comparison of outcomes between E-only MHT and unexposed subjects
| Outcome | No. of subjects (annualized %) | Unadjusted HR (95% CI) |
Adjusted HR (95% CI) |
|
|---|---|---|---|---|
| E-only MHT (n=1,208) |
E-only unexposed (n=1,997) |
|||
| Follow-up time in months mean (range) | 33.6 (6.5–127.0) | 32.7 (4.6–126.9) | NA | NA |
| Acute MI | 2 (0.06) | 5 (0.09) | 0.65 (0.13–3.33) | 0.57 (0.11–2.99) |
| CHD Death | 0 (0) | 2 (0.04) | - | - |
| CABG/PTCA | 0 (0) | 2 (0.02) | - | - |
| Breast cancer | 12 (0.36) | 24 (0.45) | 0.79 (0.40–1.58) | 0.82 (0.41–1.67) |
| Stroke | 22 (0.65) | 30 (0.56) | 1.16 (0.67–2.01) | 1.08 (0.62–1.90) |
| PE | 1 (0.03) | 1 (0.02) | 1.54 (0.10–24.73) | 1.93 (0.12–31.3) |
| DVT | 3 (0.09) | 1 (0.02) | 4.76 (0.50–45.83) | 3.99 (0.39–40.0) |
| Colon cancer | 2 (0.06) | 5 (0.09) | 0.64 (0.12–3.28) | 0.56 (0.11–3.0) |
| Endometrial cancer | 6 (0.18) | 4 (0.07) | 2.41 (0.68–8.56) | 2.20 (0.61–7.91) |
| Any cancer | 132 (4.3) | 112 (2.2) | 2.0 (1.55–2.57) | 2.01 (1.56–2.59) |
| Vertebral and hip fractures | 31 (0.93) | 48 (0.91) | 1.02 (0.65–1.60) | 1.07 (0.68–1.70) |
| Any fracture | 73 (2.2) | 128 (2.5) | 0.89 (0.67–1.19) | 0.90 (0.68–1.21) |
| Death | 47 (1.3) | 96 (1.8) | 0.77 (0.54–1.09) | 0.85 (0.59–1.22) |
| Global Index | 232 (7.8) | 315 (6.3) | 1.24 (1.05–1.47) | 1.27 (1.07–1.51) |
*
Adjusted for age, statin use, aspirin use, hypercholesterolemia, diabetes medication use, hypertension