Table 2.

Results for selected SNPs in CAMP, GACRS, BAMSE, and PACT

SNP	Chr	Allele	CAMP				GACRS			BAMSE			PACT			Combined P-values
			MAF	β	P-value	FBAT	MAF	β	FBAT	MAF	β	P-value	MAF	β	P-value	All cohorts	Replication only
rs17100817	1	A	.0295	−0.89	1.6×10−5	0.128	.0158	−0.08	0.41	.0157	0.76	0.15	.3402	n/a	0.45	2.85× 10−4	0.31
rs4658627	1	A	.2730	−0.28	3.1×10−5	0.001	.2418	−0.13	0.006	.2849	−0.16	0.19	.2160	−0.61	0.12*	5.92× 10−6	0.0068
rs9815663	3	T	.2050	−0.42	2.8×10−7	0.029	.1820	−0.17	0.075	.2011	−0.33	0.035	.1977	−0.49	0.0099	2.31× 10−8	0.0018
rs6908183	6	G	.3155	0.26	5.9×10−5	0.006	.2196	0.01	0.055	.3210	−0.02	0.44	.2665	n/a	0.20	2.00× 10−4	0.10
rs384112	6	T	.0111	−1.62	1.3×10−5	0.095	.0605	−0.06	0.38	.0085	0.65	0.29	.1017	n/a	0.47	4.00× 10−4	0.43
rs2699467	7	T	.0581	−0.59	1.2×10−5	0.155	.1262	0.15	0.47	.0668	0.07	0.41	.1195	−0.18	0.25	3.54× 10−4	0.42
rs960957	9	T	.3357	0.26	6.7×10−5	0.008	.4733	0.1	0.45	.3343	0.11	0.24	.3433	n/a	0.32	1.07× 10−3	0.35
rs7927044	11	A	.0104	−2.03	5.5×10−8	0.108	.0134	−0.16	0.36	.0156	−2.15	0.0036	.0249	0.51	0.25*	6.54× 10−9	0.013
rs7328278	13	C	.0183	−1.24	4.4×10−6	0.157	.0285	0.13	0.27	.0142	2.51	0.0084	.0189	n/a	0.19	2.98× 10−6	0.017
rs17753596	14	T	.1239	0.38	8.0×10−5	0.18	.0680	−0.11	0.11	.1686	−0.03	0.44	.0973	0.23	0.18	4.14× 10−4	0.15
rs9940339	16	T	.0262	−0.84	1.2×10−5	0.059	.0135	−0.04	0.22	.0341	−0.24	0.29	.0419	−0.09	0.39	2.07× 10−4	0.29
rs10521233	17	G	.0724	−0.63	3.6×10−8	0.032	.0735	−0.14	0.19	.0554	−0.01	0.49	.0582	−0.02	0.48	2.69× 10−6	0.40
rs2074289	17	G	.0183	−0.99	1.5×10−5	0.04	.1156	−0.04	0.24	.0312	−0.09	0.42	n/a	n/a	n/a	1.58× 10−4	0.33
rs6110858	20	A	.4342	0.25	3.9×10−5	0.137	.4620	0.07	0.096	.4632	0.04	0.4	.3655	−0.28	0.048	6.43× 10−5	0.05

SNP: Single nucleotide polymorphism. CHR: Chromosome. P-values and βs are from population-based adjusted survival analysis for age of onset, except FBAT = P-value from family-based association test (CAMP and GACR). Combined P-values were calculated using Fisher’s approach for all cohorts, and for replication cohorts only (GACRS, BAMSE and PACT), using the population-based approach P-values for CAMP, BAMSE and PACT, and the FBAT P-value for GACRS.

^*PACT genotyping performed on an Affymetrix platform, which does not include rs4658627 or rs7927044; analysis was performed using imputed genotypic data.