Table 1.
Decay-corrected in vivo distribution of 18F-Annexin V in UM-SCC-22B tumor bearing mice quantified by PET imaging (n = 9).
Organ | 30 min | 60 min | 120 min |
---|---|---|---|
Kidneys | 19.2 ± 10.2 | 7.57 ± 3.08 | 2.57 ± 0.32 |
Liver | 10.4 ± 3.50 | 5.23 ± 2.37 | 2.43 ± 0.49 |
Blood* | 2.98 ± 0.56 | 1.77 ± 0.46 | 0.85 ± 0.12 |
Tumor | 1.52 ± 0.31 | 1.04 ± 0.26 | 0.59 ± 0.08 |
Muscle | 0.69 ± 0.17 | 0.52 ± 0.24 | 0.23 ± 0.06 |
T/K | 0.09 ± 0.03 | 0.15 ± 0.03 | 0.23 ± 0.04 |
T/L | 0.15 ± 0.04 | 0.19 ± 0.01 | 0.25 ± 0.07 |
T/B | 0.51 ± 0.08 | 0.59 ± 0.06 | 0.71 ± 0.14 |
T/M | 2.27 ± 0.53 | 2.20 ± 0.67 | 2.76 ± 0.82 |
The results were presented as mean ± SD (n = 9). Uptake is expressed in %ID/g tissue. Tumor/non-tumor ratios are unitless.
Radioactivity in blood was determined by ROI over heart.
T, tumor; K, Kidneys; L, Liver; B, Blood; M, Muscle.