Table 1.
Case no. | Age (yr) | Baseline plasma ACTH (pg/ml) | Baseline UFC (μg/24 h) | 8-mg Dex suppression test (% cortisol reduction from pre- to posttest) | CRH stimulation (ovine) |
IPSS: maximum ratio of IPS ACTH to peripheral ACTH | |
---|---|---|---|---|---|---|---|
Mean % rise in ACTH at 15 and 30 min | Mean % rise in cortisol at 30 and 45 min | ||||||
1 | 7 | 41 | 9,388 | 10 | 1 | 21 | 1.2 |
2 | 13 | 222 | 1,785 | 16 | −11 | 3 | 1.2 |
3 | 14 | NA | 9,806 | 24 | −10 | −2 | NA |
4 | 17 | 87 | 777 | NA | NA | NA | 1.4 |
5 | 20 | 127 | 9,130 | NA | 14 | 4 | 1.2 |
6 | 21 | 149 | 18,390 | NA | 34 | NA | 1.6 |
7 | 24 | 362 | 8,613 | −21 | 1 | 3 | 2.3 |
8 | 27 | 333 | 3,580 | 6 | −3 | 12 | 1.2 |
9 | 40 | 149 | 8,200 | 11 | 1 | 12 | 1.4 |
10 | 50 | 59 | 2,890 | −38 | 5 | 28 | 1.6 |
11 | 51 | 385 | 2,800 | −2 | 3 | −7 | 1.4 |
Median | 21 | 149 | 5,890 | 8 | 1 | 4 | 1.4 |
UFC, Normal ranges, 20–90 μg/24 h (cases 1, 3, 5, 9, 11), 24–108 (case 7), 8–77 (case 8), and 3–45 (cases 2, 4, 10). Dex suppression, 8 mg dexamethasone given at 2400 h; CRH, 1 μg/kg ovine CRH; IPSS, after peripheral injection of 1 μg/kg ovine CRH; NA, not available. To convert ACTH from pg/ml to pmol/liter, multiply by 0.22. To convert 24-h UFC from μg to pmol, multiply by 2.76. Boldface indicates median values.