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. 2012 Apr 25;97(7):2223–2230. doi: 10.1210/jc.2011-3355

Table 1.

Biochemical data of the 11 patients evaluated for CS before resection of ACTH-producing thymic NET

Case no. Age (yr) Baseline plasma ACTH (pg/ml) Baseline UFC (μg/24 h) 8-mg Dex suppression test (% cortisol reduction from pre- to posttest) CRH stimulation (ovine)
IPSS: maximum ratio of IPS ACTH to peripheral ACTH
Mean % rise in ACTH at 15 and 30 min Mean % rise in cortisol at 30 and 45 min
1 7 41 9,388 10 1 21 1.2
2 13 222 1,785 16 −11 3 1.2
3 14 NA 9,806 24 −10 −2 NA
4 17 87 777 NA NA NA 1.4
5 20 127 9,130 NA 14 4 1.2
6 21 149 18,390 NA 34 NA 1.6
7 24 362 8,613 −21 1 3 2.3
8 27 333 3,580 6 −3 12 1.2
9 40 149 8,200 11 1 12 1.4
10 50 59 2,890 −38 5 28 1.6
11 51 385 2,800 −2 3 −7 1.4
Median 21 149 5,890 8 1 4 1.4

UFC, Normal ranges, 20–90 μg/24 h (cases 1, 3, 5, 9, 11), 24–108 (case 7), 8–77 (case 8), and 3–45 (cases 2, 4, 10). Dex suppression, 8 mg dexamethasone given at 2400 h; CRH, 1 μg/kg ovine CRH; IPSS, after peripheral injection of 1 μg/kg ovine CRH; NA, not available. To convert ACTH from pg/ml to pmol/liter, multiply by 0.22. To convert 24-h UFC from μg to pmol, multiply by 2.76. Boldface indicates median values.