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. 2012 Apr 30;97(7):E1342–E1347. doi: 10.1210/jc.2011-3478

Table 1.

Odds ratios and P values for the association of PCOS with seven SNP identified in a genome-wide association study of Chinese women

SNP allele OR Chinese Frq Chinese Samples P OR Ncases Frqcases Ncontrols Frqcontrols Pcombined OR (95% CI) PHet
rs13405728-A 1.41 0.726 Iceland 0.55 1.12 376 0.958 16,947 0.954 0.34 1.15 (0.86, 1.52) 0.98
2p16.3 Boston 0.50 1.20 554 0.949 483 0.940
Chicago 0.69 1.16 201 0.963 186 0.957
rs12468394-C 1.39 0.695 Iceland 0.32 1.08 376 0.517 16,947 0.497 0.077 1.10 (0.99–1.23) 0.75
2p21 Boston 0.36 1.09 554 0.542 483 0.521
Chicago 0.17 1.22 193 0.544 180 0.494
rs13429458-A 1.49 0.793 Iceland 0.27 1.15 376 0.892 16,947 0.879 0.60 1.05 (0.87, 1.27) 0.46
2p21 Bostona 0.96 1.01 490 0.885 297 0.884
Chicago 0.43 0.84 188 0.867 180 0.886
rs12478601-C 1.39 0.686 Iceland 0.028 1.19 376 0.504 16,947 0.470 0.18 1.09 (0.96, 1.23) 0.19
2p21 Boston 0.67 0.95 544 0.436 481 0.450
Chicago 0.71 0.94 201 0.410 184 0.424
rs10818854-A 1.51 0.079 Iceland 0.0099 1.73 376 0.057 16,947 0.037 0.0019 1.53 (1.17, 2.00) 0.65
9q33.3 Boston 0.10 1.40 565 0.060 479 0.044
Chicago 0.36 1.41 203 0.044 189 0.032
rs2479106-G 1.34 0.216 Iceland 0.34 1.09 376 0.243 16,947 0.227 0.45 1.05 (0.93, 1.18) 0.49
9q33.3 Boston 0.50 1.07 559 0.310 477 0.297
Chicago 0.42 0.88 201 0.306 188 0.332
rs10986105-C 1.47 0.069 Iceland 0.0043 1.87 376 0.055 16,947 0.034 0.00033 1.68 (1.27, 2.23) 0.39
9q33.3 Boston 0.011 1.76 554 0.056 482 0.032
Chicago 0.96 1.02 202 0.037 178 0.036

For each SNP the table includes the OR and frequency of the risk allele in the Chinese study, P value, OR, number and frequency in cases and controls for the three sample sets, and P value and OR in the samples sets combined using a Mantel-Haenszel model (18) together with a P value, PHet, for the test of heterogeneity in the effect estimates between the sample sets. The association P values are two sided and adjusted for genomic controls in Iceland (λ = 1.16). Freq, Frequency; CI, confidence interval.

a

rs13429458 failed genotyping in the MALDI-TOF mass spectrometry Sequenom platform. Data are presented for the Centaurus (Nanogen) platform only.