Table 2.
The association between metabolic health, obesity, and CVD mortality
| Cases/n | Age- and sex-adjusted HR (95% CI) | Fully adjusted HR (95% CI)a | |
|---|---|---|---|
| Whole sample | |||
| Metabolically healthy nonobese | 225/12716 | 1.00 (referent) | 1.00 |
| Metabolically unhealthy nonobese | 216/4201 | 1.66 (1.37–2.00) | 1.59 (1.30–1.94) |
| Metabolically healthy obese | 18/1160 | 1.02 (0.63–1.65) | 1.26 (0.74–2.13) |
| Metabolically unhealthy obese | 145/4128 | 1.58 (1.28–1.95) | 1.64 (1.17–2.30) |
| P trend | <0.001 | <0.001 | |
| Men | |||
| Metabolically healthy nonobese | 132/5771 | 1.00 (referent) | 1.00 |
| Metabolically unhealthy nonobese | 110/1983 | 1.45 (1.12–1.87) | 1.36 (1.04–1.78) |
| Metabolically healthy obese | 11/610 | 1.09 (0.59–2.02) | 1.45 (0.73–2.89) |
| Metabolically unhealthy obese | 79/1669 | 1.69 (1.28–2.24) | 1.84 (1.17–2.90) |
| P trend | 0.001 | 0.039 | |
| Women | |||
| Metabolically healthy nonobese | 93/6945 | 1.00 (referent) | 1.00 |
| Metabolically unhealthy nonobese | 106/2218 | 1.95 (1.47–2.59) | 1.90 (1.41–2.57) |
| Metabolically healthy obese | 7/550 | 0.95 (0.44–2.05) | 1.04 (0.45–2.38) |
| Metabolically unhealthy obese | 66/2459 | 1.47 (1.07–2.02) | 1.47 (0.88–2.46) |
| P trend | <0.001 | <0.001 |
Sample contains participants without a history of CVD at baseline (n = 22,203).
a
Contains adjustment for age, sex, smoking, physical activity, socioeconomic group, and BMI.