Table 3.

The association between metabolic health, obesity, and all-cause mortality

	Cases/n	Age- and sex-adjusted HR (95% CI)	Fully adjusted HR (95% CI)a
Whole sample
Metabolically healthy nonobese	777/12716	1.00 (referent)	1.00
Metabolically unhealthy nonobese	656/4201	1.56 (1.40–1.73)	1.59 (1.42–1.77)
Metabolically healthy obese	38/1160	0.60 (0.43–0.83)	0.91 (0.64–1.29)
Metabolically unhealthy obese	397/4128	1.25 (1.11–1.41)	1.79 (1.47–2.17)
P trend		<0.001	<0.001
Men
Metabolically healthy nonobese	417/5771	1.00 (referent)	1.00
Metabolically unhealthy nonobese	334/1983	1.46 (1.26–1.69)	1.46 (1.25–1.69)
Metabolically healthy obese	23/610	0.69 (0.45–1.05)	1.09 (0.68–1.75)
Metabolically unhealthy obese	203/1669	1.41 (1.20–1.67)	2.09 (1.60–2.73)
P trend		<0.001	<0.001
Women
Metabolically healthy nonobese	360/6945	1.00 (referent)	1.00
Metabolically unhealthy nonobese	322/2218	1.69 (1.45–1.97)	1.71 (1.45–2.01)
Metabolically healthy obese	15/550	0.51 (0.30–0.86)	0.73 (0.42–1.27)
Metabolically unhealthy obese	194/2459	1.12 (0.94–1.33)	1.56 (1.17–2.08)
P trend		<0.001	<0.001

Sample contains participants without a history of CVD at baseline (n = 22,203).

^aContains adjustment for age, sex, smoking, physical activity, socioeconomic group, and BMI.